A short update:
Updated to nginx 1.21.6 -> same problem: [error] 484#484: *26 client intended to send too large body: 10870728 bytes, client: x.x.x.x, server: xxx, request: "POST /nzbget/jsonrpc HTTP/2.0", host: "xxx", referrer: "https://xxx/nzbget/"
Updated to nginx 1.21.6 -> same problem: [error] 484#484: *26 client intended to send too large body: 10870728 bytes, client: x.x.x.x, server: xxx, request: "POST /nzbget/jsonrpc HTTP/2.0", host: "xxx", referrer: "https://xxx/nzbget/"